Can SCM use a remote database and/or can that database be on SQL Server 2008 R2?

So two questions:

1) Can SCM use a remote SQL Server database rather than on the local machine? So SCM is installed, for example on AppServer but the database we want it to use is installed on DBServer.

2) Can SCM use a SQL Server 2008 R2 database rather than just SQL Server 2008?

TIA